Hi Mason_Blu
Sorry to hear you're having trouble, you say that you've downloaded and extracted the 0.4.0 release, and when you open PyxelEdit.exe, nothing happens?
Try to follow this path, and remove the PyxelEdit folder.
Windows: C:\Users\[username]\AppData\Roaming\PyxelEdit or similar.
You can enter %appdata% as the path in windows explorer to find the Roaming folder quickly.
also in case you are using anti-virus software, check if the Pyxeledit gets quarantined or.. just disable it briefly, and try to open the Pyxeledit again.