Release 0.4.6

PyxelEdit 0.4.6 is now available!
The biggest change is 64 bit support on both Windows and Mac, supporting much higher memory use. Document saving is now done asynchronously on a background thread, which should help with the hiccups that happened on autosaving with large documents. Also, the slowdown issue is finally resolved. More changes below.
Note for Mac users! The application is now signed with a proper code signing certificate. When starting the application after updating you might encounter the following message:

This is caused by the application trying to access the stored license info, but the new certificate doesn't match the one used previously.
You may just click Always Allow (no password required) and it will work, but the recommended solution is to delete the folder ELS located in /Users/your_username/Library/Application Support/PyxelEdit/ that contains your license activation, and then activating the application again using the activation key from your license page, to avoid the problem reappearing the next time you update.
Changes
The biggest change is 64 bit support on both Windows and Mac, supporting much higher memory use. Document saving is now done asynchronously on a background thread, which should help with the hiccups that happened on autosaving with large documents. Also, the slowdown issue is finally resolved. More changes below.
Note for Mac users! The application is now signed with a proper code signing certificate. When starting the application after updating you might encounter the following message:

This is caused by the application trying to access the stored license info, but the new certificate doesn't match the one used previously.
You may just click Always Allow (no password required) and it will work, but the recommended solution is to delete the folder ELS located in /Users/your_username/Library/Application Support/PyxelEdit/ that contains your license activation, and then activating the application again using the activation key from your license page, to avoid the problem reappearing the next time you update.
Changes
Features
64 bit versions on Windows and Mac, with significantly higher memory use limits.
Background thread document saving.
Layer solo/mute visibility feature.
Set default palette for new documents.
Rough but functional user palette preset saving and loading (Color>Presets>Save current palette as a preset).
Support for larger HD cursors.
Right click context menu to document frame, with options to reveal the file in the OS file system or to close the document.
Export selected part of document, accessible from the Export menu or using the hotkey Ctrl/Cmd-Shift-R.
Experimental tile transform offset feature (enable in the Settings window).
Fixes
Fixed gradual slowdown issue.
Fixed save failing when using "Save as..." on macOS 10.13 High Sierra.
Fixed issue where the pen tool couldn't be used in the animation frame edit panel after deselecting until it was moved over the main canvas.
Fixed canvas not getting redrawn when undoing a layer deletion.
Improvements to stability on launching the program.
Fixed issue where layers with less than 100% opacity didn't render correctly after changing document tile size.
Hopefully fixed copy-paste issues on MacOS High Sierra.
Improvements
Fixed some hiccups that could occur during pen strokes.
Made adjusters not give focus to the text field when using the slider (for pen and shape tool size, opacity etc).
Made selection box and width/height indicator constrained to the canvas bounds when dragging outside canvas.
Better autosave logic to get rid of unnecessary saves when documents have not changed, and better error messages on autosave failure.
Made the window have a minimum size of 640x480, and made sure it is reachable on startup (not outside screen or begind taskbar/dock).
On saving document, also check if the file path exists before deciding on using save/saveAs.
Made document name get an incrementing suffix number when getting duplicated.
Enter/escape key bindings for confirming/cancelling in document close confirmation dialog.
Comments
@Horst: I could make a 32 bit build without too much trouble if there is demand. It does still suffer from some of the memory limit problems the previous version had though, and background document saving is a bit unstable (but disabled by default).
@TheMnk: Do you mean the locations of detached panels?
Exact, location, size and all the customizable elements of each panel.
The message is:
"The file could not be saved: error #3001"
On the other hand I wanted to check if there would be a possibility to select a default color palette which would pretty much be an addition to the idea that @TheMnk had basically.
Cheers
It is actually possible to set a default color palette now in the Color menu.
@AdamEavy @Brendonm17, thanks for the kind words!
Any chance of having a high resolution option for retina screens? Pyxel edit UI is so blurry and jaggy and killing my eyes
Not sure if this is relevant (set to high vs standard):
https://help.adobe.com/en_US/air/build/WSfffb011ac560372f2fea1812938a6e463-8000.html#WSfffb011ac560372f-4cb7055d12d779150e8-8000